This website was created as a project for Genetics 677, an undergraduate course at UW Madison.
WRN Protein
Structure of WRN 3'-5' exonuclease domain
5 protein domains exist within the WRN protein. The active-form of the WRN protein is localized in the nucleolus (within the nucleus of the cell) by a signal within the C-terminus. A conserved but unique aspect to WRN within the RecQ family of helicases is the 3'-5' exonuclease domain, which can be viewed above. Using the slide out menu while holding the cursor over "protein analysis" will navigate to WRN protein sub-menus including: homology, phylogeny, protein domains, and protein interactions.
References
1. (Title figure) 3'-5' exonuclease. Perry J., et al. (2006) WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nature structural and molecular biology 13: 414-422.
2. National Center for Biotechnology Information. Werner syndrome ATP-dependent helicase [homo sapiens]. FASTA sequence. Bethesda (MD): HUGO gene nomenclature committee; March 2010. Available from: http://www.ncbi.nlm.nih.gov/gene/7486?log$=activity
3. Gene Infinity. Molecular Weight. c2002-2010. Available from: http://geneinfinity.org/
2. National Center for Biotechnology Information. Werner syndrome ATP-dependent helicase [homo sapiens]. FASTA sequence. Bethesda (MD): HUGO gene nomenclature committee; March 2010. Available from: http://www.ncbi.nlm.nih.gov/gene/7486?log$=activity
3. Gene Infinity. Molecular Weight. c2002-2010. Available from: http://geneinfinity.org/
